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Common use

Isotretinoin is a brand isotretinoin which a form of vitamin A. This midicine is known to reduce the oil secretion from the sebaceous glands in the skin. People use Isotretinoin to treat various forms of acne. Each capsule contains other ingredients such as edetate sodium, beeswax, hydrogenated cereals, hydrogenated vegetable oil, soybean oil, and soybean oil. In gelatinous capsules there is glycerin, methyl and propyl. Isotretinoin is a crystalline powder of yellow-orange color.

This is a very powerful drug against acne. Isotretinoin chemically is very similar to retinol. The Isotretinoin exact mechanism of action hasn’t been studied yet. The preparation blocks sebaceous glands, reduces the production of fat in the skin, and thus prevents the development of acne. Isotretinoin is widespread drug in many parts of the world. The preparation is considered one of the most reliable ways to do away with acne. Bodybuilders use it to remove one of side effects of the use of AAS - acne.

Dosage

The initial dose is usually 0.5 mg/kg / day. Often at the beginning of treatment you can notice a short-time aggravation of acne. The effectiveness and side effects of the preparation vary in different patients. That's why after about four weeks of the therapy, it is necessary to correct the dose in the range from 0.1 to 1.0 mg/kg / day.

As for the highest daily dose (1 mg/kg), it ought to be administered only for a limited time. The treatment course usually lasts 16 weeks. Patients should remember that often improvement continues even after stopping using the drug. Therefore, before the re-appointment of the course you should make a break (not less than 8 weeks).

The capsule is taken during the meal - a small dose of once a day; a higher dose is divided into two doses.

Precautions

There are some precautions that patients who using Isotretinoin ought to be aware of.

Isotretinoin can lead to birth defects if the drug is taken by pregnant women. That’s why women should control not to get pregnant during the therapy.

Patients ought to avoid vitamin A supplements when using Isotretinoin. The preparation is a form of vitamin A itself, and can lead to side effects.

Patients using Isotretinoin mustn’t donate blood. If they do, it can lead to side effects. Generally, care should be taken up to one month after the treatment has been stopped.

Never use Isotretinoin if you suffer from allergy to Isotretinoin or parabens.

In case you have heart disease, or cholesterol related problem, your doctor should be informed before you start using Isotretinoin.

Patients with asthma, liver disease, diabetes, or eating disorders should also discuss these conditions with their physician if they are provided for Isotretinoin.

Avoid ultraviolet rays using Isotretinoin. They can seriously damage your skin.

Contraindications:

Never use this drug without reading all its contraindications. They include:
pregnancy,
liver and kidney failure,
hypervitaminosis A,
hyperlipidemia and increased sensitivity to resistance.

Side effects

People using AIsotretinoin should be aware of some side effects the preparation can cause.

Most of the side effects of this preparation depend on the dose.

Common side effects include hair loss, weak skin, depression, suicidal tendencies, miscarriages, birth defects, joint pain, back pain, and dryness of mucous membranes. Other side effects include tinnitus, dry eyes, eye problems, liver damage, psychosis, and erectile dysfunction. You can experience more serious side effect. They would be a heart attack, stroke, seizures, the reduction of the number of leukocytes in the blood and inflammatory bowel disease. Another common disorder that most often associated with the using of Isotretinoin for acne is Crohn's disease. Isotretinoin may also cause birth defects, when taken by pregnant women; this means that the condition of pregnant women should be tested.

Overdosage

When you will start using Isotretinoin, try to follow all the recommendations and the prescribed dosage. In case of overdose it is vital to call the doctor, since some remedial measures should be taken.

In case of accidental overdose patient will fell the symptoms of hypervitaminosis A. During the first hours after the overdose gastric lavage should be made.

Interaction

While using Isotretinoin and preparations containing vitamin A, a patient takes the risk of hypervitaminosis A. Using of tetracyclines and Isotretinoin increases the risk of intracranial hypertension